THE PROBLEM

Neurological diseases are terrible medical conditions. Many neurological diseases like stroke, amyotrophic lateral sclerosis (ALS) or Parkinson´s disease dramatically reduce the life-quality of the patients and, in the case of ALS, ultimately resulting in the death of the patient.

The main alterations observed at the cellular level in these diseases are represented in the following illustrations:

Interestingly, these cellular alterations are not limited to these diseases, but can also be observed in other neurological diseases (e.g. Alzheimer´s disease).

SOLUTION

NEUREVO has identified two innovative neuroprotective therapeutic lead candidates that effectively protect against neuronal death in multiple neurological disorders. This is achieved through:

  • the reduction of intracellular calcium
  • the protection of mitochondrial function against environmental toxins or protein aggregates and
  • an increase in energy production, thereby reverting the situation observed in diseased neurons.

* Literature
1. Chovsepian, A., et al. Glycolic acid protects neurons against ischemia in vitro and in two animal models of stroke. bioRxiv, 2020.2011.2024.396051 (2020).
2. Diez, V., Traikov, S., Schmeisser, K., Adhikari, A.K.D. & Kurzchalia, T.V. Glycolate combats massive oxidative stress by restoring redox potential in Caenorhabditis elegans. Communications Biology 4, 151 (2021).
3. Bour, S., et al. A conserved role of Parkinson-associated DJ-1 metabolites in sperm motility, mitosis, and embryonic development. bioRxiv, 2021.2001.2016.426934 (2021).